The RAMIT trial, a pragmatic RCT of cardiac rehabilitation versus usual care: what does it tell us?

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The RAMIT trial was funded in 1997 to randomise 8000 patients to cardiac rehabilitation (CR) or routine care and would have provided sufficient power to demonstrate the effect of CR on mortality in a single trial. Despite the efforts of the investigators, the study sponsors (NHS Research and Development Programme), requested early closure due to low recruitment. Given the level of all cause mortality in the control group (84/910, 9.2%) the trial would have needed around 3100 patients in each arm, to detect a 20% reduction at 80% power. In fact the study had <1000 in each arm of the trial. Despite that, over the last 10 years, the ‘negative result’ from RAMIT has been discussed widely. This is the first published account and we welcome the discussion it is provoking (see page 637).
Original languageEnglish
Pages (from-to)605-606
Number of pages2
Issue number8
Publication statusPublished - Apr 2012

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