The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease

Jirí Klempír; Olga Klempírová; Jan Stochl; Natasa Spacková; Jan Roth

doi:10.1007/s00415-009-5164-9

The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease

Jirí Klempír, Olga Klempírová, Jan Stochl, Natasa Spacková, Jan Roth

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between motor symptoms and cognitive impairment in Huntington's disease (HD) is still discussed. We analysed 45 HD patients in various stages using Unified Huntington's Disease Rating Scale motor subscale (voluntary and involuntary components were evaluated separately), verbal memory and executive functions tests. Partial correlations controlling for HD duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment. Voluntary components of motor performance were found to be significantly correlated with verbal short-term memory disturbances (r = -0.361, P = 0.03), with tests of executive functions more dependent on motor performance (r = 0.640, P

Original language	English
Pages (from-to)	1629-33
Number of pages	5
Journal	Journal of neurology
Volume	256
Issue number	10
DOIs	https://doi.org/10.1007/s00415-009-5164-9
Publication status	Published - Oct 2009

Keywords

Cognition Disorders
Dyskinesias
Humans
Huntington Disease
Neuropsychological Tests
Psychomotor Performance
Severity of Illness Index

Access to Document

10.1007/s00415-009-5164-9

Cite this

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abstract = "The relationship between motor symptoms and cognitive impairment in Huntington's disease (HD) is still discussed. We analysed 45 HD patients in various stages using Unified Huntington's Disease Rating Scale motor subscale (voluntary and involuntary components were evaluated separately), verbal memory and executive functions tests. Partial correlations controlling for HD duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment. Voluntary components of motor performance were found to be significantly correlated with verbal short-term memory disturbances (r = -0.361, P = 0.03), with tests of executive functions more dependent on motor performance (r = 0.640, P ",

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AU - Spacková, Natasa

AU - Roth, Jan

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