The role of MCM/P1 proteins in the licensing of DNA replication

J P Chong; P Thömmes; J J Blow

The role of MCM/P1 proteins in the licensing of DNA replication

J P Chong, P Thömmes, J J Blow

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

Original language	English
Pages (from-to)	102-6
Number of pages	5
Journal	Trends in biochemical sciences
Volume	21
Issue number	3
Publication status	Published - 1996

Keywords

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA Replication
DNA-Binding Proteins
Fungal Proteins
Humans
Mutation
Nuclear Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Subcellular Fractions

Cite this

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title = "The role of MCM/P1 proteins in the licensing of DNA replication",

abstract = "The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.",

keywords = "Cell Cycle Proteins, Chromosomal Proteins, Non-Histone, DNA Replication, DNA-Binding Proteins, Fungal Proteins, Humans, Mutation, Nuclear Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Subcellular Fractions",

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AU - Thömmes, P

AU - Blow, J J

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AB - The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

KW - Cell Cycle Proteins

KW - Chromosomal Proteins, Non-Histone

KW - DNA Replication

KW - DNA-Binding Proteins

KW - Fungal Proteins

KW - Humans

KW - Mutation

KW - Nuclear Proteins

KW - Saccharomyces cerevisiae

KW - Saccharomyces cerevisiae Proteins

KW - Subcellular Fractions

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SN - 0968-0004

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EP - 106

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

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