The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

J R H  Tame; S H  Sleigh; A J  Wilkinson; J E  Ladbury

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

J R H Tame, S H Sleigh, A J Wilkinson, J E Ladbury

Chemistry

Research output: Contribution to journal › Letter › peer-review

Abstract

Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.

Original language	English
Pages (from-to)	998-1001
Number of pages	4
Journal	Nature Structural Biology
Volume	3
Issue number	12
Publication status	Published - Dec 1996

Keywords

CHAIN CONFORMATIONAL ENTROPY
BOUND WATER
ESCHERICHIA-COLI
SPECIFICITY
MOLECULES
ENTHALPY

Cite this

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title = "The role of water in sequence-independent ligand binding by an oligopeptide transporter protein",

abstract = "Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.",

keywords = "CHAIN CONFORMATIONAL ENTROPY, BOUND WATER, ESCHERICHIA-COLI, SPECIFICITY, MOLECULES, ENTHALPY",

author = "Tame, {J R H} and Sleigh, {S H} and Wilkinson, {A J} and Ladbury, {J E}",

year = "1996",

month = dec,

language = "English",

volume = "3",

pages = "998--1001",

journal = "Nature Structural Biology",

issn = "1072-8368",

publisher = "Nature Publishing Group",

number = "12",

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T1 - The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

AU - Tame, J R H

AU - Sleigh, S H

AU - Wilkinson, A J

AU - Ladbury, J E

PY - 1996/12

Y1 - 1996/12

N2 - Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.

AB - Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.

KW - CHAIN CONFORMATIONAL ENTROPY

KW - BOUND WATER

KW - ESCHERICHIA-COLI

KW - SPECIFICITY

KW - MOLECULES

KW - ENTHALPY

M3 - Letter

SN - 1072-8368

VL - 3

SP - 998

EP - 1001

JO - Nature Structural Biology

JF - Nature Structural Biology

IS - 12

ER -