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The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity

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The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. / Peiter, E; Fischer, M; Sidaway, K; Roberts, S K; Sanders, D.

In: FEBS Letters, Vol. 579, No. 25, 24.10.2005, p. 5697-5703.

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Harvard

Peiter, E, Fischer, M, Sidaway, K, Roberts, SK & Sanders, D 2005, 'The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity', FEBS Letters, vol. 579, no. 25, pp. 5697-5703. https://doi.org/10.1016/j.febslet.2005.09.058

APA

Peiter, E., Fischer, M., Sidaway, K., Roberts, S. K., & Sanders, D. (2005). The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. FEBS Letters, 579(25), 5697-5703. https://doi.org/10.1016/j.febslet.2005.09.058

Vancouver

Peiter E, Fischer M, Sidaway K, Roberts SK, Sanders D. The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. FEBS Letters. 2005 Oct 24;579(25):5697-5703. https://doi.org/10.1016/j.febslet.2005.09.058

Author

Peiter, E ; Fischer, M ; Sidaway, K ; Roberts, S K ; Sanders, D. / The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. In: FEBS Letters. 2005 ; Vol. 579, No. 25. pp. 5697-5703.

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@article{e2eb0c1b28a1406bae6da382fa2204ba,
title = "The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity",
abstract = "Cch1p and Mid1p are components of a high-affinity Ca2+-permeable channel in the yeast plasma membrane. Here, we show that growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium. Both phenotypes were suppressed by high Ca2+ concentration. Iron stress elicited an increased Ca2+ influx into both wild type and cch1 Delta mid Delta yeast. Inhibition of calcineurin strongly depressed growth of iron-stressed wild type yeast, indicating that calcineurin is a downstream element of the iron stress response. Iron hypersensitivity of the cch1 Delta mid1 Delta mutant was not associated with an increased iron uptake. An involvement of oxidative stress in the iron-hypersensitive phenotype was indicated by the findings that the antioxidants tocopheryl acetate and (ethyl)glutathione improved growth and viability of the iron-stressed mutant. Further, the degree of glutathione oxidation was increased in the presence of iron. The results indicate that iron stress leads to an increased oxidative poise and that Cch1pMid1p is essential to tolerate this condition. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.",
keywords = "calcium, channel, cold stress, iron toxicity, Saccharomyces cerevisiae, OXIDATIVE STRESS, YEAST, GLUTATHIONE, INFLUX, CALCINEURIN, HOMOLOG, PROTEIN, HOMEOSTASIS, DISULFIDE, DISEASE",
author = "E Peiter and M Fischer and K Sidaway and Roberts, {S K} and D Sanders",
year = "2005",
month = oct,
day = "24",
doi = "10.1016/j.febslet.2005.09.058",
language = "English",
volume = "579",
pages = "5697--5703",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley",
number = "25",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity

AU - Peiter, E

AU - Fischer, M

AU - Sidaway, K

AU - Roberts, S K

AU - Sanders, D

PY - 2005/10/24

Y1 - 2005/10/24

N2 - Cch1p and Mid1p are components of a high-affinity Ca2+-permeable channel in the yeast plasma membrane. Here, we show that growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium. Both phenotypes were suppressed by high Ca2+ concentration. Iron stress elicited an increased Ca2+ influx into both wild type and cch1 Delta mid Delta yeast. Inhibition of calcineurin strongly depressed growth of iron-stressed wild type yeast, indicating that calcineurin is a downstream element of the iron stress response. Iron hypersensitivity of the cch1 Delta mid1 Delta mutant was not associated with an increased iron uptake. An involvement of oxidative stress in the iron-hypersensitive phenotype was indicated by the findings that the antioxidants tocopheryl acetate and (ethyl)glutathione improved growth and viability of the iron-stressed mutant. Further, the degree of glutathione oxidation was increased in the presence of iron. The results indicate that iron stress leads to an increased oxidative poise and that Cch1pMid1p is essential to tolerate this condition. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

AB - Cch1p and Mid1p are components of a high-affinity Ca2+-permeable channel in the yeast plasma membrane. Here, we show that growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium. Both phenotypes were suppressed by high Ca2+ concentration. Iron stress elicited an increased Ca2+ influx into both wild type and cch1 Delta mid Delta yeast. Inhibition of calcineurin strongly depressed growth of iron-stressed wild type yeast, indicating that calcineurin is a downstream element of the iron stress response. Iron hypersensitivity of the cch1 Delta mid1 Delta mutant was not associated with an increased iron uptake. An involvement of oxidative stress in the iron-hypersensitive phenotype was indicated by the findings that the antioxidants tocopheryl acetate and (ethyl)glutathione improved growth and viability of the iron-stressed mutant. Further, the degree of glutathione oxidation was increased in the presence of iron. The results indicate that iron stress leads to an increased oxidative poise and that Cch1pMid1p is essential to tolerate this condition. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

KW - calcium

KW - channel

KW - cold stress

KW - iron toxicity

KW - Saccharomyces cerevisiae

KW - OXIDATIVE STRESS

KW - YEAST

KW - GLUTATHIONE

KW - INFLUX

KW - CALCINEURIN

KW - HOMOLOG

KW - PROTEIN

KW - HOMEOSTASIS

KW - DISULFIDE

KW - DISEASE

U2 - 10.1016/j.febslet.2005.09.058

DO - 10.1016/j.febslet.2005.09.058

M3 - Article

VL - 579

SP - 5697

EP - 5703

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 25

ER -