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The scaffold-forming steps of plant alkaloid biosynthesis

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JournalNATURAL PRODUCT REPORTS
DateAccepted/In press - 21 Jul 2020
DatePublished (current) - 3 Aug 2021
Issue number1
Volume38
Number of pages27
Pages (from-to)103-129
Original languageEnglish

Abstract

Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a privileged position in both modern and traditional medicines. In recent years, there have been significant advances in elucidating the biosynthetic origins of plant alkaloids. In this review, I will describe the progress made in determining the metabolic origins of the so-called true alkaloids, specialised metabolites derived from amino acids containing a nitrogen heterocycle. By identifying key biosynthetic steps that feature in the majority of pathways, I highlight the key roles played by modifications to primary metabolism, iminium reactivity and spontaneous reactions in the molecular and evolutionary origins of these pathways.

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Funding Information:
The author acknowledges support from a UKRI Future Leaders Fellowship (MR/S01862X/1).

Publisher Copyright:
© The Royal Society of Chemistry.

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Copyright 2021 Elsevier B.V., All rights reserved.

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