The synthesis and evaluation of diacylglycerol analogues as potential second-messenger antagonists

J C  BRIGGS; A P  DAWSON; I  GIBSON; A H  HAINES; J  HOOK; A  LLOYD; S  MEINERS; R J K  TAYLOR

doi:10.1016/S0960-894X(01)80433-9

The synthesis and evaluation of diacylglycerol analogues as potential second-messenger antagonists

J C BRIGGS, A P DAWSON, I GIBSON, A H HAINES, J HOOK, A LLOYD, S MEINERS, R J K TAYLOR

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Structural analogues of diacylglycerol have been synthesised in an attempt to discover antagonists of protein kinase C with the aim of developing new agents for preventing cell proliferation.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(01)80433-9
Publication status	Published - 1992

Keywords

PROTEIN KINASE-C
DIFFERENTIATION
ACTIVATION

Access to Document

10.1016/S0960-894X(01)80433-9

Cite this

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title = "The synthesis and evaluation of diacylglycerol analogues as potential second-messenger antagonists",

abstract = "Structural analogues of diacylglycerol have been synthesised in an attempt to discover antagonists of protein kinase C with the aim of developing new agents for preventing cell proliferation.",

keywords = "PROTEIN KINASE-C, DIFFERENTIATION, ACTIVATION",

author = "BRIGGS, {J C} and DAWSON, {A P} and I GIBSON and HAINES, {A H} and J HOOK and A LLOYD and S MEINERS and TAYLOR, {R J K}",

year = "1992",

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language = "English",

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journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

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T1 - The synthesis and evaluation of diacylglycerol analogues as potential second-messenger antagonists

AU - BRIGGS, J C

AU - DAWSON, A P

AU - GIBSON, I

AU - HAINES, A H

AU - HOOK, J

AU - LLOYD, A

AU - MEINERS, S

AU - TAYLOR, R J K

PY - 1992

Y1 - 1992

N2 - Structural analogues of diacylglycerol have been synthesised in an attempt to discover antagonists of protein kinase C with the aim of developing new agents for preventing cell proliferation.

AB - Structural analogues of diacylglycerol have been synthesised in an attempt to discover antagonists of protein kinase C with the aim of developing new agents for preventing cell proliferation.

KW - PROTEIN KINASE-C

KW - DIFFERENTIATION

KW - ACTIVATION

U2 - 10.1016/S0960-894X(01)80433-9

DO - 10.1016/S0960-894X(01)80433-9

M3 - Article

SN - 0960-894X

VL - 2

SP - 127

EP - 130

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 2

ER -