The synthesis and use of a15n and2h isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid

G. S. Timmins; X. Wei; C. L. Hawkins; R. J.K. Taylor; M. J. Davies

doi:10.1080/13510002.1996.11747082

The synthesis and use of a¹⁵n and²h isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid

G. S. Timmins^*, X. Wei, C. L. Hawkins, R. J.K. Taylor, M. J. Davies

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report the synthesis and use of d₂-¹⁵N isotopically-labelled 3,5-dibromo-4-nitrosobenzenesulphonic acid (DBNBS-d₂-¹W, as its sodium salt), a spin-trap possessing several advantages over non-labelled DBNBS. The simplification in the electron paramagnetic resonance spectra of radical adducts of DBNBS-d₂-¹⁵Ncompared with those of DBNBS not only results in increased sensitivity, but also facilitates the assignment and analysis of complex spectra. An example of this simplification is given.

Original language	English
Pages (from-to)	407-410
Number of pages	4
Journal	REDOX REPORT
Volume	2
Issue number	6
DOIs	https://doi.org/10.1080/13510002.1996.11747082
Publication status	Published - 1996

Bibliographical note

Funding Information:
The authors would like to thank the Yorkshire Cancer Research Campaign (fellowship for GST), the University of York Innovation and Research Priming Fund (fellowship for XW), the Arthritis and Rheumatism Council (grant D0084, studentship for CUI) and the EPSRC and Association for International Cancer Research (provision of EPR facilities). We also wish to thank Professor Bruce C. Gilbert and Dr Adrian C. Whitwood for their helpful discussions of this work.

Publisher Copyright:
© Pearson Professional Ltd 1996.

Access to Document

10.1080/13510002.1996.11747082

Cite this

@article{f2fb28a0ec614c139c3b7586fc804253,

title = "The synthesis and use of a15n and2h isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid",

abstract = "We report the synthesis and use of d2-15N isotopically-labelled 3,5-dibromo-4-nitrosobenzenesulphonic acid (DBNBS-d2-1W, as its sodium salt), a spin-trap possessing several advantages over non-labelled DBNBS. The simplification in the electron paramagnetic resonance spectra of radical adducts of DBNBS-d2-15Ncompared with those of DBNBS not only results in increased sensitivity, but also facilitates the assignment and analysis of complex spectra. An example of this simplification is given.",

author = "Timmins, {G. S.} and X. Wei and Hawkins, {C. L.} and Taylor, {R. J.K.} and Davies, {M. J.}",

note = "Funding Information: The authors would like to thank the Yorkshire Cancer Research Campaign (fellowship for GST), the University of York Innovation and Research Priming Fund (fellowship for XW), the Arthritis and Rheumatism Council (grant D0084, studentship for CUI) and the EPSRC and Association for International Cancer Research (provision of EPR facilities). We also wish to thank Professor Bruce C. Gilbert and Dr Adrian C. Whitwood for their helpful discussions of this work. Publisher Copyright: {\textcopyright} Pearson Professional Ltd 1996.",

year = "1996",

doi = "10.1080/13510002.1996.11747082",

language = "English",

volume = "2",

pages = "407--410",

journal = "REDOX REPORT",

issn = "1351-0002",

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TY - JOUR

T1 - The synthesis and use of a15n and2h isotopically-labelled derivative of the spin-trap 3, 5-dibromo-4-nitrosobenzenesulphonic acid

AU - Timmins, G. S.

AU - Wei, X.

AU - Hawkins, C. L.

AU - Taylor, R. J.K.

AU - Davies, M. J.

N1 - Funding Information: The authors would like to thank the Yorkshire Cancer Research Campaign (fellowship for GST), the University of York Innovation and Research Priming Fund (fellowship for XW), the Arthritis and Rheumatism Council (grant D0084, studentship for CUI) and the EPSRC and Association for International Cancer Research (provision of EPR facilities). We also wish to thank Professor Bruce C. Gilbert and Dr Adrian C. Whitwood for their helpful discussions of this work. Publisher Copyright: © Pearson Professional Ltd 1996.

PY - 1996

Y1 - 1996

N2 - We report the synthesis and use of d2-15N isotopically-labelled 3,5-dibromo-4-nitrosobenzenesulphonic acid (DBNBS-d2-1W, as its sodium salt), a spin-trap possessing several advantages over non-labelled DBNBS. The simplification in the electron paramagnetic resonance spectra of radical adducts of DBNBS-d2-15Ncompared with those of DBNBS not only results in increased sensitivity, but also facilitates the assignment and analysis of complex spectra. An example of this simplification is given.

AB - We report the synthesis and use of d2-15N isotopically-labelled 3,5-dibromo-4-nitrosobenzenesulphonic acid (DBNBS-d2-1W, as its sodium salt), a spin-trap possessing several advantages over non-labelled DBNBS. The simplification in the electron paramagnetic resonance spectra of radical adducts of DBNBS-d2-15Ncompared with those of DBNBS not only results in increased sensitivity, but also facilitates the assignment and analysis of complex spectra. An example of this simplification is given.

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U2 - 10.1080/13510002.1996.11747082

DO - 10.1080/13510002.1996.11747082

M3 - Article

AN - SCOPUS:33846279640

SN - 1351-0002

VL - 2

SP - 407

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IS - 6