The use of wavelet transforms in low-resolution phase extension

J Wilson; P Main

The use of wavelet transforms in low-resolution phase extension

Research output: Contribution to journal › Article › peer-review

Abstract

A method to extend low-resolution phases has been developed using histogram matching not only of the electron density itself but also of histograms obtained from the different levels of detail provided by the wavelet transform of the electron density. It is shown that the method can extend phases from 10 Angstrom to around 6-7 Angstrom on a wide range of trial structures differing in size, space group and solvent content. This level of phase extension can improve the electron-density map from little more than a molecular envelope to one in which secondary structure can often be identified.

Original language	English
Pages (from-to)	625-633
Number of pages	9
Journal	Acta crystallographica section d-Biological crystallography
Volume	56
Publication status	Published - May 2000

Keywords

ELECTRON-DENSITY HISTOGRAMS
REAL-SPACE ENVELOPES
PROTEIN STRUCTURES
CRYSTAL-STRUCTURE
CRYSTALLOGRAPHY
REFINEMENT

Cite this

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title = "The use of wavelet transforms in low-resolution phase extension",

abstract = "A method to extend low-resolution phases has been developed using histogram matching not only of the electron density itself but also of histograms obtained from the different levels of detail provided by the wavelet transform of the electron density. It is shown that the method can extend phases from 10 Angstrom to around 6-7 Angstrom on a wide range of trial structures differing in size, space group and solvent content. This level of phase extension can improve the electron-density map from little more than a molecular envelope to one in which secondary structure can often be identified.",

keywords = "ELECTRON-DENSITY HISTOGRAMS, REAL-SPACE ENVELOPES, PROTEIN STRUCTURES, CRYSTAL-STRUCTURE, CRYSTALLOGRAPHY, REFINEMENT",

author = "J Wilson and P Main",

year = "2000",

month = may,

language = "English",

volume = "56",

pages = "625--633",

journal = "Acta crystallographica section d-Biological crystallography",

issn = "0907-4449",

publisher = "International Union of Crystallography",

}

TY - JOUR

T1 - The use of wavelet transforms in low-resolution phase extension

AU - Wilson, J

AU - Main, P

PY - 2000/5

Y1 - 2000/5

N2 - A method to extend low-resolution phases has been developed using histogram matching not only of the electron density itself but also of histograms obtained from the different levels of detail provided by the wavelet transform of the electron density. It is shown that the method can extend phases from 10 Angstrom to around 6-7 Angstrom on a wide range of trial structures differing in size, space group and solvent content. This level of phase extension can improve the electron-density map from little more than a molecular envelope to one in which secondary structure can often be identified.

AB - A method to extend low-resolution phases has been developed using histogram matching not only of the electron density itself but also of histograms obtained from the different levels of detail provided by the wavelet transform of the electron density. It is shown that the method can extend phases from 10 Angstrom to around 6-7 Angstrom on a wide range of trial structures differing in size, space group and solvent content. This level of phase extension can improve the electron-density map from little more than a molecular envelope to one in which secondary structure can often be identified.

KW - ELECTRON-DENSITY HISTOGRAMS

KW - REAL-SPACE ENVELOPES

KW - PROTEIN STRUCTURES

KW - CRYSTAL-STRUCTURE

KW - CRYSTALLOGRAPHY

KW - REFINEMENT

M3 - Article

SN - 0907-4449

VL - 56

SP - 625

EP - 633

JO - Acta crystallographica section d-Biological crystallography

JF - Acta crystallographica section d-Biological crystallography

ER -