Thinking quantitatively about transcriptional regulation

Sandra J Greive; Peter H von Hippel

doi:10.1038/nrm1588

Thinking quantitatively about transcriptional regulation

Sandra J Greive, Peter H von Hippel

Chemistry

Research output: Contribution to journal › Review article

Abstract

By thinking about the chemical and physical mechanisms that are involved in the stepwise elongation of RNA transcripts, we can begin to understand the way that these mechanisms are controlled within the cell to reflect the different requirements for transcription that are posed by various metabolic, developmental and disease states. Here, we focus on the mechanistic details of the single-nucleotide addition (or excision) cycle in the transcription process, as this is the level at which many regulatory mechanisms function and can be explained in quantitative terms.

Original language	English
Pages (from-to)	221-32
Number of pages	12
Journal	Nature reviews. Molecular cell biology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1038/nrm1588
Publication status	Published - Mar 2005

Keywords

DNA Helicases/physiology
DNA-Directed RNA Polymerases/physiology
Escherichia coli/genetics
Gene Expression Regulation, Bacterial/physiology
Operon/genetics
Transcription, Genetic/physiology

Access to Document

10.1038/nrm1588

Cite this

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title = "Thinking quantitatively about transcriptional regulation",

abstract = "By thinking about the chemical and physical mechanisms that are involved in the stepwise elongation of RNA transcripts, we can begin to understand the way that these mechanisms are controlled within the cell to reflect the different requirements for transcription that are posed by various metabolic, developmental and disease states. Here, we focus on the mechanistic details of the single-nucleotide addition (or excision) cycle in the transcription process, as this is the level at which many regulatory mechanisms function and can be explained in quantitative terms.",

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KW - DNA Helicases/physiology

KW - DNA-Directed RNA Polymerases/physiology

KW - Escherichia coli/genetics

KW - Gene Expression Regulation, Bacterial/physiology

KW - Operon/genetics

KW - Transcription, Genetic/physiology

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