Thiosulfonates as Emerging Reactants: Synthesis and Applications

P. Mampuys, C. R. McElroy, J. H. Clark, R. V.A. Orru, B. U.W. Maes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The synthetic strategies towards thiosulfonates (RSO2SR1) are comprehensively reviewed from their original discovery to recent advances. Incorporation of the green credentials of the synthetic procedures towards thiosulfonates allows one to judge the merits of the state of the art, beyond the typical yield of a product and availability of the reactants. As reactant for organic transformations, thiosulfonates are particularly interesting given their possibility to react with nucleophiles, electrophiles and radicals. This review aims to give researchers, not familiar with the field, a good understanding of the general applications of thiosulfonates, while not skipping the recent important advances. The related, but less explored, selenosulfonates (RSO2SeR1) are also covered. (Figure presented.).

Original languageEnglish
Number of pages63
JournalAdvanced Synthesis and Catalysis
Early online date18 Dec 2019
Publication statusE-pub ahead of print - 18 Dec 2019

Bibliographical note

© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.


  • green chemistry
  • multicomponent reactions
  • sulfur
  • synthetic applications
  • thiosulfonates

Cite this