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From the same journal

TIME for COFFEE is an essential component in the maintenance of metabolic homeostasis in Arabidopsis thaliana

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Published copy (DOI)

Author(s)

  • A. Sanchez-Villarreal
  • J. Shin
  • N. Bujdoso
  • T. Obata
  • U. Neumann
  • S.-X. Du
  • Z. Ding
  • A.M. Davis
  • T. Shindo
  • E. Schmelzer
  • R. Sulpice
  • A. Nunes-Nesi
  • M. Stitt
  • A.R. Fernie
  • S.J. Davis

Department/unit(s)

Publication details

JournalThe Plant journal
DatePublished - 1 Oct 2013
Issue number2
Volume76
Pages (from-to)188-200
Original languageEnglish

Abstract

Plants often respond to environmental changes by reprogramming metabolic and stress-associated pathways. Homeostatic integration of signaling is a central requirement for ensuring metabolic stability in living organisms. Under diurnal conditions, properly timed rhythmic metabolism provides fitness benefits to plants. TIME FOR COFFEE (TIC) is a circadian regulator known to be involved in clock resetting at dawn. Here we explored the mechanism of influence of TIC in plant growth and development, as initiated by a microarray analysis. This global profiling showed that a loss of TIC function causes a major reprogramming of gene expression that predicts numerous developmental, metabolic, and stress-related phenotypes. This led us to demonstrate that this mutant exhibits late flowering, a plastochron defect, and diverse anatomical phenotypes. We further observed a starch-excess phenotype and altered soluble carbohydrate levels. tic exhibited hypersensitivity to oxidative stress and abscisic acid, and this was associated with a striking resistance to drought. These phenotypes were connected to an increase in total glutathione levels that correlated with a readjustment of amino acids and polyamine pools. By comparatively analyzing our transcriptomic and metabolomic data, we concluded that TIC is a central element in plant homeostasis that integrates and coordinates developmental, metabolic, and environmental signals.

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