By the same authors

From the same journal

From the same journal

Total synthesis of an oxepine natural product, (±)-Janoxepin

Research output: Contribution to journalArticlepeer-review

Published copy (DOI)



Publication details

JournalOrganic Letters
DatePublished - 17 Feb 2012
Issue number4
Number of pages4
Pages (from-to)1122-1125
Original languageEnglish


The total synthesis of (±)-janoxepin, a novel antiplasmodial d-leucine derived oxepine-pyrimidinone-ketopiperazine isolated from the fungus Aspergillus janus, is described. The cornerstones of the synthetic route are pyrimidinone preparation, ring-closing metathesis, aldol introduction of the enamide, and dihydro-oxepine elaboration. This synthetic route proved very efficient for the formation of a number of janoxepin analogues, including dihydro-janoxepin and tetrahydro-janoxepin.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations