Total Synthesis of Spirobacillene A

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The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product.
Original languageEnglish
Pages (from-to)3306-3309
JournalOrganic Letters
Issue number13
Publication statusPublished - 20 Jun 2013

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