Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

Sybrin P Schroder, Jasper W van de Sande, Wouter W. Kallemeijn, Chi-Lin Kuo, Marta Artola, Eva J. van Rooden, Jianbing Jiang, Thomas JM Beenakker, Bobby I Florea, Wendy A Offen, Gideon Davies, Adriaan J. Minnaard, Hans Aerts, Jeroen D Codee, Gijsbert A. Van Der Marel, Herman S. Overkleeft

Research output: Contribution to journalArticlepeer-review


Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of [small beta]-glucosidases and [small beta]-galactosidases.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalChemical Communications
Early online date6 Nov 2017
Publication statusE-pub ahead of print - 6 Nov 2017

Bibliographical note

© 2017, The Author(s).

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