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From the same journal

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

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  • Sybrin P Schroder
  • Jasper W van de Sande
  • Wouter W. Kallemeijn
  • Chi-Lin Kuo
  • Marta Artola
  • Eva J. van Rooden
  • Jianbing Jiang
  • Thomas JM Beenakker
  • Bobby I Florea
  • Wendy A Offen
  • Gideon Davies
  • Adriaan J. Minnaard
  • Hans Aerts
  • Jeroen D Codee
  • Gijsbert A. Van Der Marel
  • Herman S. Overkleeft


Publication details

JournalChemical Communications
DateAccepted/In press - 3 Nov 2017
DateE-pub ahead of print (current) - 6 Nov 2017
Number of pages5
Pages (from-to)1-5
Early online date6/11/17
Original languageEnglish


Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of [small beta]-glucosidases and [small beta]-galactosidases.

Bibliographical note

© 2017, The Author(s).

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