By the same authors

From the same journal

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

Research output: Contribution to journalArticle

Full text download(s)

Published copy (DOI)

Author(s)

  • Sybrin P Schroder
  • Jasper W van de Sande
  • Wouter W. Kallemeijn
  • Chi-Lin Kuo
  • Marta Artola
  • Eva J. van Rooden
  • Jianbing Jiang
  • Thomas JM Beenakker
  • Bobby I Florea
  • Wendy A Offen
  • Gideon Davies
  • Adriaan J. Minnaard
  • Hans Aerts
  • Jeroen D Codee
  • Gijsbert A. Van Der Marel
  • Herman S. Overkleeft

Department/unit(s)

Publication details

JournalChemical Communications
DateAccepted/In press - 3 Nov 2017
DateE-pub ahead of print (current) - 6 Nov 2017
Number of pages5
Pages (from-to)1-5
Early online date6/11/17
Original languageEnglish

Abstract

Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of [small beta]-glucosidases and [small beta]-galactosidases.

Bibliographical note

© 2017, The Author(s).

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations