Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

Andree Iemhoff; James Sherwood; Con R. McElroy; Andrew J. Hunt

doi:10.1039/c7gc03177g

Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

Andree Iemhoff, James Sherwood, Con R. McElroy, Andrew J. Hunt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Green Chemistry
Volume	20
Issue number	1
Early online date	1 Dec 2017
DOIs	https://doi.org/10.1039/c7gc03177g
Publication status	Published - 2018

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© The Royal Society of Chemistry, 2018. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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23b PRE-PRINT Bio-catalysis in flow (Iemhoff 2018)
© The Royal Society of Chemistry, 2018. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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Cite this

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Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

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