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Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

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JournalGreen Chemistry
DateAccepted/In press - 30 Nov 2017
DateE-pub ahead of print - 1 Dec 2017
DatePublished (current) - 2018
Issue number1
Number of pages5
Pages (from-to)136-140
Early online date1/12/17
Original languageEnglish


The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.

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© The Royal Society of Chemistry, 2018. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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