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Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae

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Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae. / Ward, Jonathan S.; Morgan, Rebecca; Lynam, Jason M.; Fairlamb, Ian J S; Moir, James W B.

In: MedChemComm, Vol. 8, No. 2, 2017, p. 346-352.

Research output: Contribution to journalArticlepeer-review

Harvard

Ward, JS, Morgan, R, Lynam, JM, Fairlamb, IJS & Moir, JWB 2017, 'Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae', MedChemComm, vol. 8, no. 2, pp. 346-352. https://doi.org/10.1039/C6MD00603E

APA

Ward, J. S., Morgan, R., Lynam, J. M., Fairlamb, I. J. S., & Moir, J. W. B. (2017). Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae. MedChemComm, 8(2), 346-352. https://doi.org/10.1039/C6MD00603E

Vancouver

Ward JS, Morgan R, Lynam JM, Fairlamb IJS, Moir JWB. Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae. MedChemComm. 2017;8(2):346-352. https://doi.org/10.1039/C6MD00603E

Author

Ward, Jonathan S. ; Morgan, Rebecca ; Lynam, Jason M. ; Fairlamb, Ian J S ; Moir, James W B. / Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae. In: MedChemComm. 2017 ; Vol. 8, No. 2. pp. 346-352.

Bibtex - Download

@article{7254b1360d1a4a2a92cbb8dced2e7162,
title = "Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae",
abstract = "The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs.",
author = "Ward, {Jonathan S.} and Rebecca Morgan and Lynam, {Jason M.} and Fairlamb, {Ian J S} and Moir, {James W B}",
note = " {\textcopyright} The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details. ",
year = "2017",
doi = "10.1039/C6MD00603E",
language = "English",
volume = "8",
pages = "346--352",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Toxicity of tryptophan manganese(I) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae

AU - Ward, Jonathan S.

AU - Morgan, Rebecca

AU - Lynam, Jason M.

AU - Fairlamb, Ian J S

AU - Moir, James W B

N1 - © The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2017

Y1 - 2017

N2 - The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs.

AB - The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs.

UR - http://www.scopus.com/inward/record.url?scp=85013831078&partnerID=8YFLogxK

U2 - 10.1039/C6MD00603E

DO - 10.1039/C6MD00603E

M3 - Article

AN - SCOPUS:85013831078

VL - 8

SP - 346

EP - 352

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 2

ER -