TOXICOKINETIC-TOXICODYNAMIC MODELING OF QUANTAL AND GRADED SUBLETHAL ENDPOINTS: A BRIEF DISCUSSION OF CONCEPTS

Roman Ashauer; Annika Agatz; Carlo Albert; Virginie Ducrot; Nika Galic; Jan Hendriks; Tjalling Jager; Andreas Kretschmann; Isabel O'Connor; Mascha Nadine Rubach; Anna-Maija Nyman; Walter Schmitt; Julita Stadnicka; Paul J. van den Brink; Thomas G. Preuss

doi:10.1002/etc.639

TOXICOKINETIC-TOXICODYNAMIC MODELING OF QUANTAL AND GRADED SUBLETHAL ENDPOINTS: A BRIEF DISCUSSION OF CONCEPTS

Roman Ashauer^*, Annika Agatz, Carlo Albert, Virginie Ducrot, Nika Galic, Jan Hendriks, Tjalling Jager, Andreas Kretschmann, Isabel O'Connor, Mascha Nadine Rubach, Anna-Maija Nyman, Walter Schmitt, Julita Stadnicka, Paul J. van den Brink, Thomas G. Preuss

^*Corresponding author for this work

Environment and Geography

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined. Environ. Toxicol. Chem. 2011;30:2519-2524. (C) 2011 SETAC

Original language	English
Pages (from-to)	2519-2524
Number of pages	6
Journal	Environmental Toxicology and Chemistry
Volume	30
Issue number	11
DOIs	https://doi.org/10.1002/etc.639
Publication status	Published - Nov 2011

Keywords

Dynamic energy budget
Mechanistic effect model
DAPHNIA-MAGNA
ORGANIC-CHEMICALS
Toxicity
BIOLOGY-BASED APPROACH
TIME-VARYING CONCENTRATIONS
BINARY-MIXTURES
Dose-response
GAMMARUS-PULEX
MIXTURE TOXICITY
PULSED EXPOSURE
Adverse outcome pathway
POPULATION-DYNAMICS
HYALELLA-AZTECA

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Ashauer, R., Agatz, A., Albert, C., Ducrot, V., Galic, N., Hendriks, J., Jager, T., Kretschmann, A., O'Connor, I., Rubach, M. N., Nyman, A.-M., Schmitt, W., Stadnicka, J., van den Brink, P. J., & Preuss, T. G. (2011). TOXICOKINETIC-TOXICODYNAMIC MODELING OF QUANTAL AND GRADED SUBLETHAL ENDPOINTS: A BRIEF DISCUSSION OF CONCEPTS. Environmental Toxicology and Chemistry, 30(11), 2519-2524. https://doi.org/10.1002/etc.639

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abstract = "We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined. Environ. Toxicol. Chem. 2011;30:2519-2524. (C) 2011 SETAC",

keywords = "Dynamic energy budget, Mechanistic effect model, DAPHNIA-MAGNA, ORGANIC-CHEMICALS, Toxicity, BIOLOGY-BASED APPROACH, TIME-VARYING CONCENTRATIONS, BINARY-MIXTURES, Dose-response, GAMMARUS-PULEX, MIXTURE TOXICITY, PULSED EXPOSURE, Adverse outcome pathway, POPULATION-DYNAMICS, HYALELLA-AZTECA",

author = "Roman Ashauer and Annika Agatz and Carlo Albert and Virginie Ducrot and Nika Galic and Jan Hendriks and Tjalling Jager and Andreas Kretschmann and Isabel O'Connor and Rubach, {Mascha Nadine} and Anna-Maija Nyman and Walter Schmitt and Julita Stadnicka and {van den Brink}, {Paul J.} and Preuss, {Thomas G.}",

year = "2011",

month = nov,

doi = "10.1002/etc.639",

language = "English",

volume = "30",

pages = "2519--2524",

journal = "Environmental Toxicology and Chemistry",

issn = "0730-7268",

publisher = "Wiley-Blackwell",

number = "11",

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Ashauer, R , Agatz, A, Albert, C, Ducrot, V, Galic, N, Hendriks, J, Jager, T, Kretschmann, A, O'Connor, I, Rubach, MN, Nyman, A-M, Schmitt, W, Stadnicka, J, van den Brink, PJ & Preuss, TG 2011, 'TOXICOKINETIC-TOXICODYNAMIC MODELING OF QUANTAL AND GRADED SUBLETHAL ENDPOINTS: A BRIEF DISCUSSION OF CONCEPTS', Environmental Toxicology and Chemistry, vol. 30, no. 11, pp. 2519-2524. https://doi.org/10.1002/etc.639

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AU - Agatz, Annika

AU - Albert, Carlo

AU - Ducrot, Virginie

AU - Galic, Nika

AU - Hendriks, Jan

AU - Jager, Tjalling

AU - Kretschmann, Andreas

AU - O'Connor, Isabel

AU - Rubach, Mascha Nadine

AU - Nyman, Anna-Maija

AU - Schmitt, Walter

AU - Stadnicka, Julita

AU - van den Brink, Paul J.

AU - Preuss, Thomas G.

PY - 2011/11

Y1 - 2011/11

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AB - We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined. Environ. Toxicol. Chem. 2011;30:2519-2524. (C) 2011 SETAC

KW - Dynamic energy budget

KW - Mechanistic effect model

KW - DAPHNIA-MAGNA

KW - ORGANIC-CHEMICALS

KW - Toxicity

KW - BIOLOGY-BASED APPROACH

KW - TIME-VARYING CONCENTRATIONS

KW - BINARY-MIXTURES

KW - Dose-response

KW - GAMMARUS-PULEX

KW - MIXTURE TOXICITY

KW - PULSED EXPOSURE

KW - Adverse outcome pathway

KW - POPULATION-DYNAMICS

KW - HYALELLA-AZTECA

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U2 - 10.1002/etc.639

DO - 10.1002/etc.639

M3 - Article

SN - 0730-7268

VL - 30

SP - 2519

EP - 2524

JO - Environmental Toxicology and Chemistry

JF - Environmental Toxicology and Chemistry

IS - 11

ER -

TOXICOKINETIC-TOXICODYNAMIC MODELING OF QUANTAL AND GRADED SUBLETHAL ENDPOINTS: A BRIEF DISCUSSION OF CONCEPTS

Abstract

Keywords

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