Transcription factors in eukaryotic cells can functionally regulate gene expression by acting in oligomeric assemblies formed from an intrinsically disordered protein phase transition enabled by molecular crowding

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DateAccepted/In press - 3 May 2018
DateE-pub ahead of print - 12 Jun 2018
DatePublished (current) - 9 Aug 2018
Number of pages12
Early online date12/06/18
Original languageEnglish

Abstract

High-speed single-molecule fluorescence microscopy in vivo shows that transcription factors in eukaryotes can act in oligomeric clusters mediated by molecular crowding and intrinsically disordered protein. This finding impacts on the longstanding puzzle of how transcription factors find their gene targets so efficiently in the complex, heterogeneous environment of the cell.

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