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From the same journal

Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000

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Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000. / Lewis, Laura A.; Polanski, Krzysztof; de Torres-Zabala, Marta; Jayaraman, Siddharth; Bowden, Laura; Moore, Jonathan; Penfold, Christopher A.; Jenkins, Dafyd J.; Hill, Claire; Baxter, Laura; Kulasekaran, Satish; Truman, William; Littlejohn, George; Prusinska, Justyna; Mead, Andrew; Steinbrenner, Jens; Hickman, Richard; Rand, David; Wild, David L.; Ott, Sascha; Buchanan-Wollaston, Vicky; Smirnoff, Nick; Beynon, Jim; Denby, Katherine; Grant, Murray.

In: The Plant Cell, Vol. 27, No. 11, 13.11.2015, p. 3038-3064.

Research output: Contribution to journalArticlepeer-review

Harvard

Lewis, LA, Polanski, K, de Torres-Zabala, M, Jayaraman, S, Bowden, L, Moore, J, Penfold, CA, Jenkins, DJ, Hill, C, Baxter, L, Kulasekaran, S, Truman, W, Littlejohn, G, Prusinska, J, Mead, A, Steinbrenner, J, Hickman, R, Rand, D, Wild, DL, Ott, S, Buchanan-Wollaston, V, Smirnoff, N, Beynon, J, Denby, K & Grant, M 2015, 'Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000', The Plant Cell, vol. 27, no. 11, pp. 3038-3064. https://doi.org/10.1105/tpc.15.00471

APA

Lewis, L. A., Polanski, K., de Torres-Zabala, M., Jayaraman, S., Bowden, L., Moore, J., Penfold, C. A., Jenkins, D. J., Hill, C., Baxter, L., Kulasekaran, S., Truman, W., Littlejohn, G., Prusinska, J., Mead, A., Steinbrenner, J., Hickman, R., Rand, D., Wild, D. L., ... Grant, M. (2015). Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000. The Plant Cell, 27(11), 3038-3064. https://doi.org/10.1105/tpc.15.00471

Vancouver

Lewis LA, Polanski K, de Torres-Zabala M, Jayaraman S, Bowden L, Moore J et al. Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000. The Plant Cell. 2015 Nov 13;27(11):3038-3064. https://doi.org/10.1105/tpc.15.00471

Author

Lewis, Laura A. ; Polanski, Krzysztof ; de Torres-Zabala, Marta ; Jayaraman, Siddharth ; Bowden, Laura ; Moore, Jonathan ; Penfold, Christopher A. ; Jenkins, Dafyd J. ; Hill, Claire ; Baxter, Laura ; Kulasekaran, Satish ; Truman, William ; Littlejohn, George ; Prusinska, Justyna ; Mead, Andrew ; Steinbrenner, Jens ; Hickman, Richard ; Rand, David ; Wild, David L. ; Ott, Sascha ; Buchanan-Wollaston, Vicky ; Smirnoff, Nick ; Beynon, Jim ; Denby, Katherine ; Grant, Murray. / Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000. In: The Plant Cell. 2015 ; Vol. 27, No. 11. pp. 3038-3064.

Bibtex - Download

@article{2cc69e6799bc4d529286b35132e61c04,
title = "Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000",
abstract = "Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses. A major challenge to understanding disease and defense responses is discriminating between transcriptional reprogramming associated with microbial-associated molecular pattern (MAMP)-triggered immunity (MTI) and that orchestrated by effectors. A high-resolution time course of genome-wide expression changes following challenge with Pseudomonas syringae pv tomato DC3000 and the nonpathogenic mutant strain DC3000hrpA allowed us to establish causal links between the activities of pathogen effectors and suppression of MTI and infer with high confidence a range of processes specifically targeted by effectors. Analysis of this information-rich data set with a range of computational tools provided insights into the earliest transcriptional events triggered by effector delivery, regulatory mechanisms recruited, and biological processes targeted. We show that the majority of genes contributing to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplication. Suppression of chloroplast-associated genes is a rapid MAMP-triggered defense response, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related genes coincide with pathogen-induced abscisic acid accumulation. Specific combinations of promoter motifs are engaged in fine-tuning the MTI response and active transcriptional suppression at specific promoter configurations by P. syringae.",
author = "Lewis, {Laura A.} and Krzysztof Polanski and {de Torres-Zabala}, Marta and Siddharth Jayaraman and Laura Bowden and Jonathan Moore and Penfold, {Christopher A.} and Jenkins, {Dafyd J.} and Claire Hill and Laura Baxter and Satish Kulasekaran and William Truman and George Littlejohn and Justyna Prusinska and Andrew Mead and Jens Steinbrenner and Richard Hickman and David Rand and Wild, {David L.} and Sascha Ott and Vicky Buchanan-Wollaston and Nick Smirnoff and Jim Beynon and Katherine Denby and Murray Grant",
year = "2015",
month = nov,
day = "13",
doi = "10.1105/tpc.15.00471",
language = "English",
volume = "27",
pages = "3038--3064",
journal = "The Plant Cell",
issn = "1040-4651",
publisher = "American Society of Plant Biologists",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000

AU - Lewis, Laura A.

AU - Polanski, Krzysztof

AU - de Torres-Zabala, Marta

AU - Jayaraman, Siddharth

AU - Bowden, Laura

AU - Moore, Jonathan

AU - Penfold, Christopher A.

AU - Jenkins, Dafyd J.

AU - Hill, Claire

AU - Baxter, Laura

AU - Kulasekaran, Satish

AU - Truman, William

AU - Littlejohn, George

AU - Prusinska, Justyna

AU - Mead, Andrew

AU - Steinbrenner, Jens

AU - Hickman, Richard

AU - Rand, David

AU - Wild, David L.

AU - Ott, Sascha

AU - Buchanan-Wollaston, Vicky

AU - Smirnoff, Nick

AU - Beynon, Jim

AU - Denby, Katherine

AU - Grant, Murray

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses. A major challenge to understanding disease and defense responses is discriminating between transcriptional reprogramming associated with microbial-associated molecular pattern (MAMP)-triggered immunity (MTI) and that orchestrated by effectors. A high-resolution time course of genome-wide expression changes following challenge with Pseudomonas syringae pv tomato DC3000 and the nonpathogenic mutant strain DC3000hrpA allowed us to establish causal links between the activities of pathogen effectors and suppression of MTI and infer with high confidence a range of processes specifically targeted by effectors. Analysis of this information-rich data set with a range of computational tools provided insights into the earliest transcriptional events triggered by effector delivery, regulatory mechanisms recruited, and biological processes targeted. We show that the majority of genes contributing to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplication. Suppression of chloroplast-associated genes is a rapid MAMP-triggered defense response, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related genes coincide with pathogen-induced abscisic acid accumulation. Specific combinations of promoter motifs are engaged in fine-tuning the MTI response and active transcriptional suppression at specific promoter configurations by P. syringae.

AB - Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses. A major challenge to understanding disease and defense responses is discriminating between transcriptional reprogramming associated with microbial-associated molecular pattern (MAMP)-triggered immunity (MTI) and that orchestrated by effectors. A high-resolution time course of genome-wide expression changes following challenge with Pseudomonas syringae pv tomato DC3000 and the nonpathogenic mutant strain DC3000hrpA allowed us to establish causal links between the activities of pathogen effectors and suppression of MTI and infer with high confidence a range of processes specifically targeted by effectors. Analysis of this information-rich data set with a range of computational tools provided insights into the earliest transcriptional events triggered by effector delivery, regulatory mechanisms recruited, and biological processes targeted. We show that the majority of genes contributing to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplication. Suppression of chloroplast-associated genes is a rapid MAMP-triggered defense response, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related genes coincide with pathogen-induced abscisic acid accumulation. Specific combinations of promoter motifs are engaged in fine-tuning the MTI response and active transcriptional suppression at specific promoter configurations by P. syringae.

UR - http://www.scopus.com/inward/record.url?scp=84949633785&partnerID=8YFLogxK

U2 - 10.1105/tpc.15.00471

DO - 10.1105/tpc.15.00471

M3 - Article

AN - SCOPUS:84949633785

VL - 27

SP - 3038

EP - 3064

JO - The Plant Cell

JF - The Plant Cell

SN - 1040-4651

IS - 11

ER -