Transition-metal catalyzed modification of nucleosides

Vijay Gayakhe, Shatrughn Bhilare, Afsana Yashmeen, Ian J.S. Fairlamb, Anant R. Kapdi

Research output: Chapter in Book/Report/Conference proceedingChapter


The importance of modified nucleosides in chemical biology as possible fluorescent probes and/or antivirals has provided researchers with the added impetus to develop efficient synthetic routes. Palladium-catalyzed processes may well be the preferred choice for such transformations but the unique reactivity exhibited by other transition metals such as Cu, Ni, Pt, Ru, Rh and others have also contributed immensely towards obtaining functionalized nucleosides with improved properties. Although the number of examples are quite limited compared to the palladium-based processes, these catalytic reactions provide researchers with possible synthetic alternatives that could be explored in the future for the development of effective multifunctional nucleoside analogs.

Original languageEnglish
Title of host publicationPalladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
Number of pages29
ISBN (Electronic)9780128112922
ISBN (Print)9780128112939
Publication statusPublished - 1 Jan 2018


  • Carbanucleosides
  • Copper
  • Fluorescent nucleosides
  • Modification
  • Nucleosides
  • Rhodium
  • Transition metal-catalyzed reactions
  • Transition metals

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