Transition-metal catalyzed modification of nucleosides

Vijay Gayakhe; Shatrughn Bhilare; Afsana Yashmeen; Ian J.S. Fairlamb; Anant R. Kapdi

doi:10.1016/B978-0-12-811292-2.00006-4

Transition-metal catalyzed modification of nucleosides

Vijay Gayakhe, Shatrughn Bhilare, Afsana Yashmeen, Ian J.S. Fairlamb, Anant R. Kapdi

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The importance of modified nucleosides in chemical biology as possible fluorescent probes and/or antivirals has provided researchers with the added impetus to develop efficient synthetic routes. Palladium-catalyzed processes may well be the preferred choice for such transformations but the unique reactivity exhibited by other transition metals such as Cu, Ni, Pt, Ru, Rh and others have also contributed immensely towards obtaining functionalized nucleosides with improved properties. Although the number of examples are quite limited compared to the palladium-based processes, these catalytic reactions provide researchers with possible synthetic alternatives that could be explored in the future for the development of effective multifunctional nucleoside analogs.

Original language	English
Title of host publication	Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
Publisher	Elsevier
Pages	167-195
Number of pages	29
ISBN (Electronic)	9780128112922
ISBN (Print)	9780128112939
DOIs	https://doi.org/10.1016/B978-0-12-811292-2.00006-4
Publication status	Published - 1 Jan 2018

Keywords

Carbanucleosides
Copper
Fluorescent nucleosides
Modification
Nucleosides
Rhodium
Transition metal-catalyzed reactions
Transition metals

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10.1016/B978-0-12-811292-2.00006-4

Cite this

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AU - Gayakhe, Vijay

AU - Bhilare, Shatrughn

AU - Yashmeen, Afsana

AU - Fairlamb, Ian J.S.

AU - Kapdi, Anant R.

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KW - Carbanucleosides

KW - Copper

KW - Fluorescent nucleosides

KW - Modification

KW - Nucleosides

KW - Rhodium

KW - Transition metal-catalyzed reactions

KW - Transition metals

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PB - Elsevier

ER -

Transition-metal catalyzed modification of nucleosides

Abstract

Keywords

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