The importance of modified nucleosides in chemical biology as possible fluorescent probes and/or antivirals has provided researchers with the added impetus to develop efficient synthetic routes. Palladium-catalyzed processes may well be the preferred choice for such transformations but the unique reactivity exhibited by other transition metals such as Cu, Ni, Pt, Ru, Rh and others have also contributed immensely towards obtaining functionalized nucleosides with improved properties. Although the number of examples are quite limited compared to the palladium-based processes, these catalytic reactions provide researchers with possible synthetic alternatives that could be explored in the future for the development of effective multifunctional nucleoside analogs.
|Title of host publication
|Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
|Number of pages
|Published - 1 Jan 2018
- Fluorescent nucleosides
- Transition metal-catalyzed reactions
- Transition metals