Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?

Shaun Treweek; Simon Bevan; Peter Bower; Marion K Campbell; Jacquie Christie; Mike Clarke; Clive Collett; Seonaidh Cotton; Declan Devane; Adel El Feky; Ella Flemyng; Sandra Galvin; Heidi Gardner; Katie Gillies; Jan Jansen; Roberta Littleford; Adwoa Parker; Craig Ramsay; Lynne Restrup; Frank Sullivan; David Torgerson; Liz Tremain; Matthew Westmore; Paula R Williamson

doi:10.1186/s13063-018-2535-5

Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?

Shaun Treweek, Simon Bevan, Peter Bower, Marion K Campbell, Jacquie Christie, Mike Clarke, Clive Collett, Seonaidh Cotton, Declan Devane, Adel El Feky, Ella Flemyng, Sandra Galvin, Heidi Gardner, Katie Gillies, Jan Jansen, Roberta Littleford, Adwoa Parker, Craig Ramsay, Lynne Restrup, Frank SullivanDavid Torgerson, Liz Tremain, Matthew Westmore, Paula R Williamson

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency.One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

Original language	English
Number of pages	5
Journal	Trials
Volume	19
Issue number	1
Early online date	23 Feb 2018
DOIs	https://doi.org/10.1186/s13063-018-2535-5
Publication status	E-pub ahead of print - 23 Feb 2018

Bibliographical note

Keywords

Letter

Access to Document

10.1186/s13063-018-2535-5

s13063-018-2535-5
© The Author(s). 2018
Final published version, 458 KBLicence: CC BY

Cite this

Treweek, S., Bevan, S., Bower, P., Campbell, M. K., Christie, J., Clarke, M., Collett, C., Cotton, S., Devane, D., El Feky, A., Flemyng, E., Galvin, S., Gardner, H., Gillies, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., ... Williamson, P. R. (2018). Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)? Trials, 19(1). Advance online publication. https://doi.org/10.1186/s13063-018-2535-5

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title = "Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?",

abstract = "Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency.One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.",

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Treweek, S, Bevan, S, Bower, P, Campbell, MK, Christie, J, Clarke, M, Collett, C, Cotton, S, Devane, D, El Feky, A, Flemyng, E, Galvin, S, Gardner, H, Gillies, K, Jansen, J, Littleford, R, Parker, A, Ramsay, C, Restrup, L, Sullivan, F, Torgerson, D, Tremain, L, Westmore, M & Williamson, PR 2018, 'Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?', Trials, vol. 19, no. 1. https://doi.org/10.1186/s13063-018-2535-5

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AU - Treweek, Shaun

AU - Bevan, Simon

AU - Bower, Peter

AU - Campbell, Marion K

AU - Christie, Jacquie

AU - Clarke, Mike

AU - Collett, Clive

AU - Cotton, Seonaidh

AU - Devane, Declan

AU - El Feky, Adel

AU - Flemyng, Ella

AU - Galvin, Sandra

AU - Gardner, Heidi

AU - Gillies, Katie

AU - Jansen, Jan

AU - Littleford, Roberta

AU - Parker, Adwoa

AU - Ramsay, Craig

AU - Restrup, Lynne

AU - Sullivan, Frank

AU - Torgerson, David

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AU - Westmore, Matthew

AU - Williamson, Paula R

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AB - Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency.One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

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