Tributyltin hydride-mediated tandem reactions of dehydroalanines leading to α-substituted pyroglutamates

S. C. Baker, K. Goodall, A. F. Parsons*, M. Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Tributyltin hydride-mediated cyclisation of dehydroalanines produces an intermediate captodative radical, which can be trapped by reaction with oxygen- or carbon-centred radicals or (principally) electron-poor alkenes, to provide a quick approach to a variety of α-substituted pyroglutamates.

Original languageEnglish
Pages (from-to)312-313
Number of pages2
JournalJournal of Chemical Research - Part S
Issue number7
Publication statusPublished - 2000

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