Tripartite ATP-independent periplasmic transporters: application of a relational database for genome-wide analysis of transporter gene frequency and organization

Research output: Contribution to journalArticlepeer-review

Abstract

Tripartite ATP-independent periplasmic (TRAP) transporters are a family of extracytoplasmic solute receptor-dependent secondary transporters that are widespread in the prokaryotic world but which have not been extensively studied. Here, we present results of a genome-wide analysis of TRAP sequences and genome organization from application of TRAPDb, a relational database created for the collection, curation and analysis of TRAP sequences. This has revealed a specific enrichment in the number of TRAP transporters in several bacteria which is consistent with increased use of TRAP transporters in saline environments. Additionally, we report a number of new organizations of TRAP transporter genes and proteins which suggest the recruitment of TRAP transporter components for use in other biological contexts.

Original languageEnglish
Pages (from-to)218-26
Number of pages9
JournalJournal of molecular microbiology and biotechnology
Volume12
Issue number3-4
DOIs
Publication statusPublished - 2007

Bibliographical note

(c) 2007 S. Karger AG, Basel.

Keywords

  • Bacteria/enzymology
  • Biological Transport/genetics
  • Carrier Proteins/chemistry
  • Computational Biology/methods
  • Databases, Genetic
  • Gene Order
  • Genes, Bacterial
  • Genome, Bacterial
  • Models, Molecular
  • Periplasmic Proteins/chemistry
  • Synteny

Cite this