Research output: Contribution to journal › Article › peer-review
Journal | Angewandte Chemie International Edition |
---|---|
Date | Published - 27 Apr 2012 |
Issue number | 18 |
Volume | 51 |
Number of pages | 4 |
Pages (from-to) | 4431-4434 |
Original language | English |
Three at the same time: A ligation strategy combining tetrazine-norbornene cycloaddition, Staudinger-Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation reactions enables selective monitoring of multiple targets at the same time in complex biological samples.
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