Tuberculosis patients learning about second-hand smoke (TBLASS): results of a pilot randomised controlled trial

TY - JOUR

T1 - Tuberculosis patients learning about second-hand smoke (TBLASS)

T2 - results of a pilot randomised controlled trial

AU - Safdar, N

AU - Zahid, R

AU - Shah, S

AU - Fatima, R

AU - Cameron, I

AU - Siddiqi, K

PY - 2015/2/1

Y1 - 2015/2/1

N2 - BACKGROUND: Passive smoking is associated with tuberculosis (TB). Measures are required to protect non-smoking TB patients from second-hand smoke (SHS).SETTING: We developed a behavioural intervention to encourage TB patients to implement smoking restrictions at home in Pakistan.OBJECTIVES: To assess the likelihood of such an intervention being successful and to inform a definitive trial in future.DESIGN: This was a pilot randomised controlled trial in which non-smoking TB patients were randomised to receive either individual-based support or individual-based support combined with family reminders. We recruited patients living with at least one smoker in their homes. Our primary outcome was urinary cotinine level as a measure of SHS exposure 2 months post-randomisation.RESULTS: Of 273 patients assessed for eligibility, 150 (56%) patients were recruited and all but one were retained throughout the trial. A statistically significant absolute reduction was observed in non-smoking participants' exposure to SHS based on urinary cotinine levels in both Arm 1 (71%, 95%CI 61-79) and Arm 2 (76%, 95%CI 67-83) between baseline and follow-up at 2 months.CONCLUSIONS: The recruitment and retention rates for trial participants make it feasible to conduct a definitive trial in future. The observed effect size makes it worthwhile to conduct such a trial.

AB - BACKGROUND: Passive smoking is associated with tuberculosis (TB). Measures are required to protect non-smoking TB patients from second-hand smoke (SHS).SETTING: We developed a behavioural intervention to encourage TB patients to implement smoking restrictions at home in Pakistan.OBJECTIVES: To assess the likelihood of such an intervention being successful and to inform a definitive trial in future.DESIGN: This was a pilot randomised controlled trial in which non-smoking TB patients were randomised to receive either individual-based support or individual-based support combined with family reminders. We recruited patients living with at least one smoker in their homes. Our primary outcome was urinary cotinine level as a measure of SHS exposure 2 months post-randomisation.RESULTS: Of 273 patients assessed for eligibility, 150 (56%) patients were recruited and all but one were retained throughout the trial. A statistically significant absolute reduction was observed in non-smoking participants' exposure to SHS based on urinary cotinine levels in both Arm 1 (71%, 95%CI 61-79) and Arm 2 (76%, 95%CI 67-83) between baseline and follow-up at 2 months.CONCLUSIONS: The recruitment and retention rates for trial participants make it feasible to conduct a definitive trial in future. The observed effect size makes it worthwhile to conduct such a trial.

KW - Passive smoking

KW - Smoke-free homes

KW - Tobacco

KW - Tuberculosis

U2 - 10.5588/ijtld.14.0615

DO - 10.5588/ijtld.14.0615

M3 - Article

C2 - 25574925

VL - 19

SP - 237

EP - 243

JO - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

SN - 1027-3719

IS - 2

ER -