Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance

Fabiola Martin; John Lee; Emma Thomson; Nick Tarrant; Antony Hale; Charles J. Lacey

doi:10.1177/0956462415571671

Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance

Fabiola Martin^*, John Lee, Emma Thomson, Nick Tarrant, Antony Hale, Charles J. Lacey

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient’s specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.

Original language	English
Pages (from-to)	66-69
Number of pages	4
Journal	International journal of STD & AIDS
Volume	27
Issue number	1
Early online date	7 Feb 2015
DOIs	https://doi.org/10.1177/0956462415571671
Publication status	Published - 1 Jan 2016

Bibliographical note

Keywords

AIDS
antiviral
dual infection
hepatitis C
high-risk behaviour
highly active antiretroviral therapy
HIV
minority species
superinfection
syphilis (Treponema pallidum)
Transmitted drug resistance
viral disease

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10.1177/0956462415571671

Int J STD AIDS-2016-Martin-66-9
© Authors 2015
Final published version, 278 KBLicence: CC BY

Cite this

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title = "Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance",

abstract = "In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient{\textquoteright}s specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.",

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AU - Hale, Antony

AU - Lacey, Charles J.

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KW - dual infection

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KW - superinfection

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Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance

Abstract

Bibliographical note

Keywords

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Cite this