Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling

G J O Evans, M A Cousin

Research output: Contribution to journalArticlepeer-review


The integral SV (synaptic vesicle) protein synaptophysin was one of the first nerve terminal proteins identified. However its role, if any, in the SV life cycle remains undetermined. one of the most prominent features of synaptophysin is that its cytoplasmic C-terminus largely consists of pentapeptide repeats initiated by a tyrosine residue. Synaptophysin is heavily phosphorylated by tyrosine kinases in the nerve terminal, suggesting that this phosphorylation is central to its function. This review will cover the evidence for tyrosine phosphorylation of synaptophysin and how this phosphorylation may control its function in the SV life cycle.

Original languageEnglish
Pages (from-to)1350-1353
Number of pages4
JournalBiochemical Society transactions
Publication statusPublished - Dec 2005

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