Ubiquitin and ubiquitin-like conjugation systems in trypanosomatids

TY - JOUR

T1 - Ubiquitin and ubiquitin-like conjugation systems in trypanosomatids

AU - Burge, Rebecca J.

AU - Mottram, Jeremy C.

AU - Wilkinson, Anthony J.

N1 - Funding Information: This work was supported by a Medical Research Council Studentship to RB ( MRC MR/N018230/ ) and the Wellcome Trust to JCM ( 200807/Z/16/Z ). Publisher Copyright: © 2022 The Authors

PY - 2022/12

Y1 - 2022/12

N2 - In eukaryotic cells, reversible attachment of ubiquitin and ubiquitin-like modifiers (Ubls) to specific target proteins is conducted by multicomponent systems whose collective actions control protein fate and cell behaviour in precise but complex ways. In trypanosomatids, attachment of ubiquitin and Ubls to target proteins regulates the cell cycle, endocytosis, protein sorting and degradation, autophagy and various aspects of infection and stress responses. The extent of these systems in trypanosomatids has been surveyed in recent reports, while in Leishmania mexicana, essential roles have been defined for many ubiquitin-system genes in deletion mutagenesis and life-cycle phenotyping campaigns. The first steps to elucidate the pathways of ubiquitin transfer among the ubiquitination components and to define the acceptor substrates and the downstream deubiquitinases are now being taken.

AB - In eukaryotic cells, reversible attachment of ubiquitin and ubiquitin-like modifiers (Ubls) to specific target proteins is conducted by multicomponent systems whose collective actions control protein fate and cell behaviour in precise but complex ways. In trypanosomatids, attachment of ubiquitin and Ubls to target proteins regulates the cell cycle, endocytosis, protein sorting and degradation, autophagy and various aspects of infection and stress responses. The extent of these systems in trypanosomatids has been surveyed in recent reports, while in Leishmania mexicana, essential roles have been defined for many ubiquitin-system genes in deletion mutagenesis and life-cycle phenotyping campaigns. The first steps to elucidate the pathways of ubiquitin transfer among the ubiquitination components and to define the acceptor substrates and the downstream deubiquitinases are now being taken.

UR - http://www.scopus.com/inward/record.url?scp=85137639506&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2022.102202

DO - 10.1016/j.mib.2022.102202

M3 - Review article

C2 - 36099676

AN - SCOPUS:85137639506

SN - 1369-5274

VL - 70

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

M1 - 102202

ER -