U.K. Controlled trial of intrapleural streptokinase for pleural infection

Nicholas A Maskell, Christopher W H Davies, Andrew J Nunn, Emma L Hedley, Fergus V Gleeson, Robert Miller, Rhian Gabe, Glyn L Rees, Timothy E A Peto, Mark A Woodhead, Donald J Lane, Janet H Darbyshire, Robert J O Davies, First Multicenter Intrapleural Sepsis Trial (MIST1) Group

Research output: Contribution to journalArticlepeer-review


Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase.
Original languageEnglish
Pages (from-to)865-74
Number of pages10
JournalThe New England journal of medicine
Issue number9
Publication statusPublished - 2005

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