Ultra-selective 1D clean in-phase correlation spectroscopy

Daniel A Taylor; Peter Kiraly; Paul Bowyer; Mathias Nilsson; Laura Castañar; Gareth A Morris; Ralph W Adams

doi:10.1039/d3cc01333b

Ultra-selective 1D clean in-phase correlation spectroscopy

Daniel A Taylor, Peter Kiraly, Paul Bowyer, Mathias Nilsson, Laura Castañar, Gareth A Morris, Ralph W Adams^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.

Original language	English
Pages (from-to)	6734-6737
Number of pages	4
Journal	Chemical communications
Volume	59
Issue number	44
Early online date	20 Apr 2023
DOIs	https://doi.org/10.1039/d3cc01333b
Publication status	Published - 4 Jun 2023
Externally published	Yes

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10.1039/d3cc01333bLicence: CC BY

Cite this

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AU - Kiraly, Peter

AU - Bowyer, Paul

AU - Nilsson, Mathias

AU - Castañar, Laura

AU - Morris, Gareth A

AU - Adams, Ralph W

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AB - Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.

U2 - 10.1039/d3cc01333b

DO - 10.1039/d3cc01333b

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