Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in Acute Myeloid Leukemia

Antoniana Batsivari, William George Grey, Dominique Bonnet

Research output: Contribution to journalReview articlepeer-review


Acute myeloid leukemia (AML) is a heterogeneous disease, yet clinically most patients present with pancytopenia resulting from bone marrow failure, predisposing them to life-threatening infections and bleeding. The mechanisms by which AML mediates hematopoietic suppression is not well known. Indeed, much effort has so far been focused on how AML remodels the bone marrow niche to make it a more permissive environment, with less focus on how the remodeled niche affects normal hematopoietic cells. In this perspective, we present evidence of the key role of the bone marrow niche in suppressing hematopoietic stem cells (HSCs) during leukemic progression and provide perspectives on how future research on this topic may be exploited to provide treatments for one of the key complications of AML.
Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalExperimental Haematology
Early online date23 Jan 2021
Publication statusPublished - 1 Mar 2021

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