Understanding the Role of Spiroindolenines in Pictet-Spengler Reactions

TY - JOUR

T1 - Understanding the Role of Spiroindolenines in Pictet-Spengler Reactions

AU - Unsworth, William P.

PY - 2018/8/9

Y1 - 2018/8/9

N2 - Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis. Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis.

AB - Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis. Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis.

UR - http://www.scopus.com/inward/record.url?scp=85050468006&partnerID=8YFLogxK

U2 - 10.1016/j.chempr.2018.07.012

DO - 10.1016/j.chempr.2018.07.012

M3 - Review article

AN - SCOPUS:85050468006

SN - 2451-9308

VL - 4

SP - 1767

EP - 1770

JO - Chem

JF - Chem

IS - 8

ER -