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Understanding the Role of Spiroindolenines in Pictet-Spengler Reactions

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JournalChem
DatePublished - 9 Aug 2018
Issue number8
Volume4
Number of pages4
Pages (from-to)1767-1770
Original languageEnglish

Abstract

Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis. Despite being discovered over a century ago, a unified mechanistic understanding of the Pictet-Spengler reaction continues to elude us. In this issue of Chem, Zheng et al. go a long way toward finally answering this long-standing and occasionally controversial mechanistic puzzle by combining density functional theory with molecular dynamics in an innovative analysis.

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