Unexpected Preferential Dehydration of Artemisinin in Ionic Liquids

TY - JOUR

T1 - Unexpected Preferential Dehydration of Artemisinin in Ionic Liquids

AU - Sanders, Marc W.

AU - Wright, Lawrence

AU - Tate, Lauren

AU - Fairless, Gayle

AU - Crowhurst, Lorna

AU - Bruce, Neil C.

AU - Walker, Adam J.

AU - Hembury, Guy A.

AU - Shimizu, Seishi

PY - 2009/9/24

Y1 - 2009/9/24

N2 - Thermodynamic measurements (at 298 K) reveal that a crucial step in the extraction process of the key antimalarial drug artemisinin by ionic liquids (ILs), namely, precipitation through the addition of water, is driven by artemisinin dehydration due to the differences in the water's interaction with the bulk ILs, rather than with the artemisinin itself.

AB - Thermodynamic measurements (at 298 K) reveal that a crucial step in the extraction process of the key antimalarial drug artemisinin by ionic liquids (ILs), namely, precipitation through the addition of water, is driven by artemisinin dehydration due to the differences in the water's interaction with the bulk ILs, rather than with the artemisinin itself.

KW - INTERACTION COEFFICIENTS

KW - TEMPERATURE

KW - HYDRATION

KW - ETHANOL

UR - http://www.scopus.com/inward/record.url?scp=70349247802&partnerID=8YFLogxK

U2 - 10.1021/jp906436e

DO - 10.1021/jp906436e

M3 - Article

SN - 1089-5639

VL - 113

SP - 10143

EP - 10145

JO - Journal of Physical Chemistry A

JF - Journal of Physical Chemistry A

IS - 38

ER -