Unified mild reaction conditions for C2-selective Pd-catalysed tryptophan arylation, including tryptophan-containing peptides

Alan J. Reay, Thomas J. Williams, Ian J S Fairlamb*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Pd-mediated C-H bond functionalisation protocols have been designed and developed on tryptophan derivatives and tryptophan-containing peptides. The examination of different arylation reactions (three sets of different conditions A-C), all of which are notable for their low temperatures (≤40°C), allowed identification of unified and complementary synthetic approaches toward a series of functionalised tryptophan-containing products. Tryptophan-containing peptides demonstrated to be susceptible to aromatic oxidation were successfully and selectively modified through the application of diaryliodonium salts in good yields.

Original languageEnglish
Pages (from-to)8298-8309
Number of pages12
JournalOrganic and Biomolecular Chemistry
Issue number30
Publication statusPublished - 14 Aug 2015

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