Unprecedented meta-substitution of calixarenes: Direct way to inherently chiral derivatives

Petr Slavik, Miroslav Dudic, Karolina Flidrova, Jan Sykora, Ivana Cisarova, Stanislav Böhm, Pavel Lhotak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Electrophilic aromatic substitution in the calix[n]arene series is a well-established procedure leading exclusively to para-substituted derivatives. An unprecedented regioselectivity of the mercuration reaction leading to the meta-substituted calix[4]arenes is described. These compounds represent a new type of substitution pattern in classical calixarene chemistry and open the door for the straightforward synthesis of inherently chiral receptors based on calixarenes.

Original languageEnglish
Pages (from-to)3628-3631
Number of pages4
JournalOrganic Letters
Issue number14
Publication statusPublished - 20 Jul 2012

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