'Upenamide: trials and tribulations

William P Unsworth; Richard J K Taylor

doi:10.1039/c3ob41519h

'Upenamide: trials and tribulations

William P Unsworth, Richard J K Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The complex macrocycle 'upenamide was isolated in 2000, stimulating significant effort from synthetic chemists to complete its total synthesis and verify its structure. Progress made by several groups is detailed, culminating in the synthesis of both of the proposed structures of this unique natural product, neither of which matched the natural material according to spectroscopic analysis. The evolution of the synthetic route and the development of associated methodologies are described.

Original language	English
Pages (from-to)	7250-7261
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	42
DOIs	https://doi.org/10.1039/c3ob41519h
Publication status	Published - 14 Nov 2013

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10.1039/c3ob41519h

http://pubs.rsc.org/en/Content/ArticleLanding/2013/OB/c3ob41519h#!divAbstract

Cite this

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abstract = "The complex macrocycle 'upenamide was isolated in 2000, stimulating significant effort from synthetic chemists to complete its total synthesis and verify its structure. Progress made by several groups is detailed, culminating in the synthesis of both of the proposed structures of this unique natural product, neither of which matched the natural material according to spectroscopic analysis. The evolution of the synthetic route and the development of associated methodologies are described.",

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AB - The complex macrocycle 'upenamide was isolated in 2000, stimulating significant effort from synthetic chemists to complete its total synthesis and verify its structure. Progress made by several groups is detailed, culminating in the synthesis of both of the proposed structures of this unique natural product, neither of which matched the natural material according to spectroscopic analysis. The evolution of the synthetic route and the development of associated methodologies are described.

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