Uptake and depuration of pharmaceuticals in aquatic invertebrates

Melanie Meredith-Williams, Laura J. Carter, Richard Fussell, David Raffaelli, Roman Ashauer, Alistair B. A. Boxall

Research output: Contribution to journalArticlepeer-review

Abstract

The uptake and depuration of a range of pharmaceuticals in the freshwater shrimp (Gammarus pulex) and the water boatman (Notonecta glauca) was studied. For one compound, studies were also done using the freshwater snail Planobarius corneus. In G. pulex, bioconcentration factors (BCFs) ranged from 4.6 to 185,900 and increased in the order moclobemide < 5-fluoruracil < carbamazepine < diazepam < carvedilol < fluoxetine. In N. glauca BCFs ranged from 0.1 to 1.6 and increased in the order 5-fluorouracil < carbamazepine < moclobemide < diazepam < fluoxetine < carvedilol. For P. corneus, the BCF for carvedilol was 57.3. The differences in degree of uptake across the three organisms may be due to differences in mode of respiration, behaviour and the pH of the test system. BCFs of the pharmaceuticals for each organism were correlated to the pH-corrected liposome-water partition coefficient of the pharmaceuticals. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)250-258
Number of pages9
JournalEnvironmental Pollution
Volume165
DOIs
Publication statusPublished - Jun 2012

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