Use of a regulatory mechanism of sex determination in pest insect control

Tarig Dafa'alla; Guoliang Fu; Luke Alphey

doi:10.1007/s12041-010-0041-y

Use of a regulatory mechanism of sex determination in pest insect control

Tarig Dafa'alla, Guoliang Fu, Luke Alphey^*

^*Corresponding author for this work

Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

The sexual development of an insect is defined through a hierarchical control of several sex determining genes. Of these genes, transformer (tra) and doublesex (dsx) are well characterized and functionally conserved, especially dsx. Both genes are regulated at the transcriptional level through sex-specific alternative splicing. Incorporation of a genetically engineered sexspecific splicing module derived from these genes in transgenic systems, such as RIDL (release of insects carrying a dominant lethal), would allow the production of male-only insects for control programmes without any physical intervention.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Journal of Genetics
Volume	89
Issue number	3
DOIs	https://doi.org/10.1007/s12041-010-0041-y
Publication status	Published - Sept 2010

Keywords

doublesex
pest insect control
RIDL
sex determination
transformer

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AB - The sexual development of an insect is defined through a hierarchical control of several sex determining genes. Of these genes, transformer (tra) and doublesex (dsx) are well characterized and functionally conserved, especially dsx. Both genes are regulated at the transcriptional level through sex-specific alternative splicing. Incorporation of a genetically engineered sexspecific splicing module derived from these genes in transgenic systems, such as RIDL (release of insects carrying a dominant lethal), would allow the production of male-only insects for control programmes without any physical intervention.

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Use of a regulatory mechanism of sex determination in pest insect control

Abstract

Keywords

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