Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

TY - JOUR

T1 - Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

AU - Norcott, Philip

AU - Burns, Michael J.

AU - Rayner, Peter J.

AU - Mewis, Ryan E.

AU - Duckett, Simon B.

N1 - .This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2018/1/25

Y1 - 2018/1/25

N2 - By introducing a range of 2H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

AB - By introducing a range of 2H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

UR - http://www.scopus.com/inward/record.url?scp=85041048830&partnerID=8YFLogxK

U2 - 10.1002/mrc.4703

DO - 10.1002/mrc.4703

M3 - Article

AN - SCOPUS:85041048830

SN - 0749-1581

JO - MAGNETIC RESONANCE IN CHEMISTRY

JF - MAGNETIC RESONANCE IN CHEMISTRY

ER -