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Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

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DateAccepted/In press - 10 Dec 2017
DateE-pub ahead of print (current) - 25 Jan 2018
Number of pages9
Early online date25/01/18
Original languageEnglish


By introducing a range of 2H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

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