Using feedback to regulate gene expression in a developmental control architecture

Kester Clegg; Susan Stepney; Tim Clarke

Using feedback to regulate gene expression in a developmental control architecture

Research output: Contribution to conference › Paper

Abstract

We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developmental processes and its mechanisms have recently become much clearer due to evidence from evolutionary developmental biology. We believe that without similar mechanisms of in- teraction and feedback, digital genomes cannot guide themselves across functional search spaces in a way that fully exploits a domain's resources, particularly in the complex search domains of real-world physics. Our architecture is designed to let evolution utilise feedback as part of its mechanism of exploration.

Original language	Undefined/Unknown
Pages	966-973
Publication status	Published - 2007

Access to Document

http://doi.acm.org/10.1145/1276958.1277154

Cite this

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title = "Using feedback to regulate gene expression in a developmental control architecture",

abstract = "We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developmental processes and its mechanisms have recently become much clearer due to evidence from evolutionary developmental biology. We believe that without similar mechanisms of in- teraction and feedback, digital genomes cannot guide themselves across functional search spaces in a way that fully exploits a domain's resources, particularly in the complex search domains of real-world physics. Our architecture is designed to let evolution utilise feedback as part of its mechanism of exploration.",

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AU - Stepney, Susan

AU - Clarke, Tim

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AB - We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developmental processes and its mechanisms have recently become much clearer due to evidence from evolutionary developmental biology. We believe that without similar mechanisms of in- teraction and feedback, digital genomes cannot guide themselves across functional search spaces in a way that fully exploits a domain's resources, particularly in the complex search domains of real-world physics. Our architecture is designed to let evolution utilise feedback as part of its mechanism of exploration.

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