Using meta-analysis to plan further research.

TY - CHAP

T1 - Using meta-analysis to plan further research.

AU - Rothery, Claire

AU - Griffin, Susan

AU - Koffijberg, H

AU - Claxton, Karl Philip

N1 - Publisher Copyright: © 2021 Taylor & Francis Group, LLC.

PY - 2020

Y1 - 2020

N2 - This chapter illustrates how value of information analysis can be applied to standard results of meta-analysis to inform a number of important policy questions, using a case study of corticosteroids after traumatic brain injury. Value of information analysis provides a framework to assess the need for additional evidence, the consequences of uncertainty, and the relative priority of alternative topics for research prioritization decisions. It can be used to establish: (1) whether the evidence currently available is sufficient to support the use of the intervention in practice, i.e., whether on balance the evidence from the meta-analysis suggests that the intervention achieves better outcomes than the available alternatives; (2) whether additional evidence might be needed to resolve uncertainty in the range of plausible values; (3) what type and design of research might resolve this uncertainty; (4) whether it would be better to withhold the intervention until additional evidence becomes available; and (5) whether any proposed research is considered a priority relative to other topics competing for the same resources.

AB - This chapter illustrates how value of information analysis can be applied to standard results of meta-analysis to inform a number of important policy questions, using a case study of corticosteroids after traumatic brain injury. Value of information analysis provides a framework to assess the need for additional evidence, the consequences of uncertainty, and the relative priority of alternative topics for research prioritization decisions. It can be used to establish: (1) whether the evidence currently available is sufficient to support the use of the intervention in practice, i.e., whether on balance the evidence from the meta-analysis suggests that the intervention achieves better outcomes than the available alternatives; (2) whether additional evidence might be needed to resolve uncertainty in the range of plausible values; (3) what type and design of research might resolve this uncertainty; (4) whether it would be better to withhold the intervention until additional evidence becomes available; and (5) whether any proposed research is considered a priority relative to other topics competing for the same resources.

UR - http://www.scopus.com/inward/record.url?scp=85163554312&partnerID=8YFLogxK

U2 - 10.1201/9781315119403-23

DO - 10.1201/9781315119403-23

M3 - Chapter

AN - SCOPUS:85163554312

SN - 9781498703987

T3 - Handbooks of Modern Statistical Methods

SP - 523

EP - 543

BT - Handbook of Meta-analysis

A2 - Schmid, C

A2 - Stijnen, T

A2 - White, I

PB - Chapman and Hall/CRCPress

ER -