Utilisation of supercritical fluids for the effective extraction of waxes and Cannabidiol (CBD) from hemp wastes

TY - JOUR

T1 - Utilisation of supercritical fluids for the effective extraction of waxes and Cannabidiol (CBD) from hemp wastes

AU - Attard, Thomas Michael

AU - Bainier, Camille

AU - Reinaud, Marine

AU - Lanot, Alexandra

AU - McQueen Mason, Simon John

AU - Hunt, Andrew

N1 - © 2017 Elsevier B.V. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Up to 33% of hemp by mass can be lost in the form of dust during processing for fibre production. Heptane Soxhlet extractions and supercritical carbon dioxide extractions (scCO2) of hemp dust samples yielded significant quantities of high value lipophilic molecules including fatty acids, policosanols (fatty alcohols), fatty aldehydes, hydrocarbons, sterols, triterpenoids and cannabinoids (cannabidiol (CBD)). Dust collected from different stages of the mechanical processing of hemp fibres gave rise to lipophilic extractives with varying compositions, thus making the isolation and purification of these compounds easier. Of particular interest is CBD (5832.5 ± 118.9 μg/g of dust), which has attracted much attention for clinical-level studies due to its therapeutic efficacy in the treatment of a variety of central nervous system (CNS) disorders. Factorial experimental design was carried out to optimise the scCO2 extraction, with 350 bar and 50 °C yielding the selective extraction of higher value components.

AB - Up to 33% of hemp by mass can be lost in the form of dust during processing for fibre production. Heptane Soxhlet extractions and supercritical carbon dioxide extractions (scCO2) of hemp dust samples yielded significant quantities of high value lipophilic molecules including fatty acids, policosanols (fatty alcohols), fatty aldehydes, hydrocarbons, sterols, triterpenoids and cannabinoids (cannabidiol (CBD)). Dust collected from different stages of the mechanical processing of hemp fibres gave rise to lipophilic extractives with varying compositions, thus making the isolation and purification of these compounds easier. Of particular interest is CBD (5832.5 ± 118.9 μg/g of dust), which has attracted much attention for clinical-level studies due to its therapeutic efficacy in the treatment of a variety of central nervous system (CNS) disorders. Factorial experimental design was carried out to optimise the scCO2 extraction, with 350 bar and 50 °C yielding the selective extraction of higher value components.

KW - Hemp

KW - Supercritical

KW - Extraction

KW - Carbon dioxide

KW - Waxes

KW - Cannabidiol

U2 - 10.1016/j.indcrop.2017.10.045

DO - 10.1016/j.indcrop.2017.10.045

M3 - Article

SN - 0926-6690

VL - 112

SP - 38

EP - 46

JO - INDUSTRIAL CROPS AND PRODUCTS

JF - INDUSTRIAL CROPS AND PRODUCTS

ER -