Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods

TY - JOUR

T1 - Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods

AU - Lloyd, Lyrelle S.

AU - Adams, Ralph W.

AU - Bernstein, Michael

AU - Coombes, Steven

AU - Duckett, Simon B.

AU - Green, Gary G. R.

AU - Lewis, Richard. J.

AU - Mewis, Ryan E.

AU - Sleigh, Christopher J.

PY - 2012/8/8

Y1 - 2012/8/8

N2 - The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of C-13, C-13{H-1}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established.

AB - The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of C-13, C-13{H-1}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established.

UR - http://www.scopus.com/inward/record.url?scp=84864666255&partnerID=8YFLogxK

U2 - 10.1021/ja3051052

DO - 10.1021/ja3051052

M3 - Article

SN - 0002-7863

VL - 134

SP - 12904

EP - 12907

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 31

ER -