Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli

TY - JOUR

T1 - Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli

AU - Ward, Jonathan S.

AU - Lynam, Jason M.

AU - Moir, James

AU - Fairlamb, Ian J S

PY - 2014/11/10

Y1 - 2014/11/10

N2 - The first visible-light-activated carbon-monoxidereleasing molecule (CO-RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophanderived manganese-containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable.

AB - The first visible-light-activated carbon-monoxidereleasing molecule (CO-RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophanderived manganese-containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable.

KW - Carbon monoxide

KW - Circular dichroism

KW - Kinetics

KW - Photochemistry

UR - http://www.scopus.com/inward/record.url?scp=84915731606&partnerID=8YFLogxK

U2 - 10.1002/chem.201403305

DO - 10.1002/chem.201403305

M3 - Article

AN - SCOPUS:84915731606

SN - 0947-6539

VL - 20

SP - 15061

EP - 15068

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 46

ER -