Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli

Jonathan S. Ward, Jason M. Lynam*, James Moir, Ian J S Fairlamb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The first visible-light-activated carbon-monoxidereleasing molecule (CO-RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophanderived manganese-containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable.

Original languageEnglish
Pages (from-to)15061-15068
Number of pages8
JournalChemistry - A European Journal
Issue number46
Early online date3 Oct 2014
Publication statusPublished - 10 Nov 2014


  • Carbon monoxide
  • Circular dichroism
  • Kinetics
  • Photochemistry

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