Abstract
The development and application of traceless acceptor groups in photochemical C−C bond formation is described. This strategy was enabled by the photoexcitation of electron donor–acceptor (EDA) complexes with visible light. The traceless acceptors, which were readily prepared from amino acid and peptide feedstocks, could be used to alkylate a wide range of heteroarene and enamine donors under metal- and peroxide-free conditions. The crucial role of the EDA complexes in the mechanism of these reactions was explored through combined experimental and computational studies.
| Original language | English |
|---|---|
| Pages (from-to) | 8240-8244 |
| Number of pages | 5 |
| Journal | Chemistry - A European Journal |
| Volume | 25 |
| Issue number | 35 |
| Early online date | 22 May 2019 |
| DOIs | |
| Publication status | Published - 24 Jun 2019 |
Bibliographical note
© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.Keywords
- amino acids
- C−C bond formation
- donor–acceptor systems
- traceless acceptors
- visible light
Profiles
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Michael John James
- Chemistry - Leverhulme Early Career Research Fellow, Former employee
Person: Research